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myelin — Engelska översättning - TechDico

Immunohistochemistry-Paraffin: CD47 Antibody (B6H12.2) - Azide Free [NBP2-31106] - Tissue section of human normal breast using mouse monoclonal CD47 antibody (clone B6H12.2) at 0.5ug/ml concentration. 2010-09-03 · Highlights CD47 is a prognostic factor and therapeutic target in non-Hodgkin Lymphoma (NHL) Anti-CD47 antibody synergizes with rituximab to eradicate NHL in vitro and in vivo Antibody synergy occurs by Fc receptor-independent and -dependent mechanisms Anti-CD47 mAb synergy with FcR-activating mAbs may be applicable to other cancers We have developed a next-generation humanized anti-CD47 antibody, AO-176, that not only blocks the CD47/SIRPα interaction to induce tumor cell phagocytosis, but also induces tumor cytotoxicity in hematologic and solid human tumor cell lines, but not normal noncancerous cells, by a cell autonomous mechanism (not ADCC). CD47 was detected in immersion fixed paraffin-embedded sections of human placenta using 5 µg/mL Sheep Anti-Human CD47 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4670) overnight at 4 °C. There are currently no images for CD47 Antibody (NBP2-90088). Every product we sell is backed by Novus' 100% Guarantee.If you have used this product, please submit your images and reviews to earn reward points.

Cd47 antibody

"Surface Oncology" announces moving their CD47 antibody into clinical trials in 2017, partnered with Novartis. Anti-CD47 Antibodies Destroys a Variety of Human Cancers Study to Advance to Human Trials "It is the first antibody treatment shown to be broadly effective company developing next-generation antibody therapies focused on the tumor microenvironment with lead programs targeting CD73, CD39, IL-27 and CD47. 23, EP13849989.2, EP2925782. ANTI-CD47 ANTIBODIES AND METHODS OF USE THEREOF. A61K39/00; C07K16/28; C07K16/46. NovImmune SA. 2013-12- 2013-11-15.

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Gene Ontology (GO) annotations related to this gene include thrombospondin receptor activity. Anti-CD47 antibody–mediated phagocytosis of cancer by macrophages can initiate an antitumor T-cell immune response.

myelin — Engelska översättning - TechDico

Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. CD47 is the receptor for thrombospondin. T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin). Recently stimulation of CD47 by monoclonal antibody has been shown to induce CD4+CD25- suppressive activity also increasing expression of Foxp3. Here, we report the identification of CD47, a protein that inhibits phagocytosis, as an antibody target in standard and high-risk ALL. CD47 was found to be more highly expressed on a subset of human ALL patient samples compared with normal cell counterparts and to be an independent predictor of survival and disease refractoriness in several ALL patient cohorts.

CD47 Antibodies CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. CD47 is the receptor for thrombospondin. T cell expression of CD47 can mediate activation or apoptosis (in the presence of high levels of thrombospondin).

Weissman och hans kollegor fann för ett decennium sedan att leukemiceller tillverkar ett protein som heter CD47.
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This antibody reacts with human samples. Cat.No. 20305-1-AP. Therapeutic antibody targeting of CD47 could be an effective therapy for PEL. PMID: 24726056 Data indicate that CD47 in cis interactions regulate LFA-1 (integrin alphaLbeta2) and VLA-4 (integrin alpha4beta1) integrin affinity, and this process plays a substantial role in the adhesion of T-cells.